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ScerTF

Details for FHL1

The Table below describes all of the matrices annotated to FHL1 in this database. For each individual matrix, we provide several metrics related to the performance of that matrix in accurately representing the DNA binding specificity of the annotated transcription factor. The Fisher's p-value represents the probability that the recommended matrix identified FHL1-bound promoters by random chance. If no experimental data exists for this particular TF, the field is labeled as "No Data". In addition to benchmarking against high-throughput experimental data, we also inform our recommendations based on matrix information content, length, and corroboration by experimental studies of individual of cis-regulatory sequences.

Each individual matrix can be downloaded as a position count matrix (PCM), position frequency matrix (PFM), or position weight matrix (PWM). Click on the appropriate button in the left column to download the desired matrix.

Also provided is a recommended cutoff to use when scanning a genome for regulatory sequences with the provided position weight matrix. An optimal cutoff was identified for each position weight matrix that provides the greatest discriminative power to distinguish between bound and unbound sequences in available ChIP experiments.

Recommended Matrix:
For information about selection criteria click here

Source

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Detailed Information

FHL1

Matrices:




Data Source:
Zhu et. al.
Fisher's P-value
2.44e-10


Information Content
10.956

Max PWM Score
9.8

Recommended PWM Cutoff
4.92
Recommended Position Specific Matrix for FHL1 comes from Zhu et. al.
 
FHL1: Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants
Aliases: YPR104C, SPP42
Genes Bound in FHL1 ChIP-chip: YAL022C, YBL072C, YBL087C, YBL092W, YBL093C, YBR012W-A, YBR012W-B, YBR084C-A, YBR085W, YBR116C, YBR117C, YBR118W, YBR126C, YBR181C, YBR184W, YBR188C, YBR189W, YBR190W +189 more
Genes affected by FHL1 deletion: No Data
TF-TF interactions for FHL1: AFT2, RAP1, SFP1
Click here to see target gene co-expression data supporting TF-TF interaction predictions


Additional Candidate Matrices:
Source
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Detailed Information
FHL1

Matrices:




Data Source:
Morozov et. al.
Fisher's P-value
3.34e-127


Information Content
14.283

Max PWM Score
14.17

Recommended PWM Cutoff
9.38
FHL1

Matrices:




Data Source:
Harbison et. al.
Fisher's P-value
1.25e-110


Information Content
11.847

Max PWM Score
12.45

Recommended PWM Cutoff
8.63
FHL1

Matrices:




Data Source:
Macisaac et. al
Fisher's P-value
4.55e-95


Information Content
11.937

Max PWM Score
11.57

Recommended PWM Cutoff
7.42
FHL1_A

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
1.13e-84


Information Content
11.848

Max PWM Score
12.76

Recommended PWM Cutoff
8.57
FHL1_D

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
1.69e-41


Information Content
18.302

Max PWM Score
16.48

Recommended PWM Cutoff
9.41
FHL1

Matrices:




Data Source:
Zhao and Stormo
Fisher's P-value
1.67e-13


Information Content
5.818

Max PWM Score
6.81

Recommended PWM Cutoff
5.73
FHL1

Matrices:




Data Source:
Badis et. al.
Fisher's P-value
6.29e-11


Information Content
10.928

Max PWM Score
8.75

Recommended PWM Cutoff
4.75
FHL1

Matrices:




Data Source:
Pachkov et al
Fisher's P-value
1.73e-10


Information Content
11.318

Max PWM Score
12.49

Recommended PWM Cutoff
7.01
FHL1_B

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
0.4630


Information Content
21.198

Max PWM Score
24.84

Recommended PWM Cutoff
13.0
FHL1_C

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
0.5224


Information Content
22.147

Max PWM Score
25.02

Recommended PWM Cutoff
13.96