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ScerTF

Details for SFP1

The Table below describes all of the matrices annotated to SFP1 in this database. For each individual matrix, we provide several metrics related to the performance of that matrix in accurately representing the DNA binding specificity of the annotated transcription factor. The Fisher's p-value represents the probability that the recommended matrix identified SFP1-bound promoters by random chance. If no experimental data exists for this particular TF, the field is labeled as "No Data". In addition to benchmarking against high-throughput experimental data, we also inform our recommendations based on matrix information content, length, and corroboration by experimental studies of individual of cis-regulatory sequences.

Each individual matrix can be downloaded as a position count matrix (PCM), position frequency matrix (PFM), or position weight matrix (PWM). Click on the appropriate button in the left column to download the desired matrix.

Also provided is a recommended cutoff to use when scanning a genome for regulatory sequences with the provided position weight matrix. An optimal cutoff was identified for each position weight matrix that provides the greatest discriminative power to distinguish between bound and unbound sequences in available ChIP experiments.

Recommended Matrix:
For information about selection criteria click here

Source

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Detailed Information

SFP1

Matrices:




Data Source:
Zhu et. al.
Fisher's P-value
0.0009


Information Content
9.055

Max PWM Score
10.53

Recommended PWM Cutoff
6.35
Recommended Position Specific Matrix for SFP1 comes from Zhu et. al.
 
SFP1: Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p
Aliases: YLR403W
Genes Bound in SFP1 ChIP-chip: YAL022C, YAR047C, YBR012C, YBR013C, YBR048W, YBR181C, YDL075W, YDL076C, YDL082W, YDL083C, YDL133W, YDR112W, YDR470C, YDR471W, YEL054C, YER078C, YER079W, YER116C +44 more
Genes affected by SFP1 deletion: YBL113C, YBR034C, YCL050C, YCR012W, YCL055W, YDR064W, YDR432W, YDR370C, YER112W, YER145C, YER118C, YGL199C, YGL171W, YGL234W, YGR278W, YIL078W, YIL142W +1587 more
TF-TF interactions for SFP1: AFT2, FHL1, RAP1
Click here to see target gene co-expression data supporting TF-TF interaction predictions


Additional Candidate Matrices:
Source
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Detailed Information
SFP1

Matrices:




Data Source:
Macisaac et. al
Fisher's P-value
1.85e-30


Information Content
12.605

Max PWM Score
11.49

Recommended PWM Cutoff
8.49
SFP1

Matrices:




Data Source:
Harbison et. al.
Fisher's P-value
4.53e-29


Information Content
8.299

Max PWM Score
10.57

Recommended PWM Cutoff
7.41
SFP1_C

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
1.31e-21


Information Content
10.572

Max PWM Score
11.25

Recommended PWM Cutoff
7.81
SFP1_B

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
7.16e-07


Information Content
15.952

Max PWM Score
14.28

Recommended PWM Cutoff
10.84
SFP1_A

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
0.0593


Information Content
12.968

Max PWM Score
13.32

Recommended PWM Cutoff
8.39
SFP1_D

Matrices:




Data Source:
Foat et. al.
Fisher's P-value
0.1353


Information Content
17.958

Max PWM Score
18.5

Recommended PWM Cutoff
12.99
SFP1

Matrices:




Data Source:
Zhao and Stormo
Fisher's P-value
1.0000


Information Content
1.593

Max PWM Score
3.82

Recommended PWM Cutoff
3.79